Yes. You most certainly can.But here's the deal, 2 things:1.) The max capability of the RAID-0 array will be determined by the HDD with the lowest performance in terms of random access time, read time, write time, and data burst.2.) The largest size of the array will be 2x the size of the smallest HDD. In your case500GB x 2 = 1TBNote, that it's NOT 500GB + 1.5 TB = 2TB.So there will be 1TB of wasted space.***