Can I do RAID 0 setup in these 2 Hard Drives?

It's best to have 2 Identical hard drives in a RAID0 configuration. Two different size HD's with different caches will defeat the purpouse of RAID0 (speed) bacause one is larger, and the other has a small cache.
 
Yes. You most certainly can.But here's the deal, 2 things:1.) The max capability of the RAID-0 array will be determined by the HDD with the lowest performance in terms of random access time, read time, write time, and data burst.2.) The largest size of the array will be 2x the size of the smallest HDD. In your case500GB x 2 = 1TBNote, that it's NOT 500GB + 1.5 TB = 2TB.So there will be 1TB of wasted space.***
 
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